...Combination Therapy Produces Synergistic EffectsThe use of several different products allows slightly lower doses, which diminishes the risk for side effects.When benzoyl peroxide is combined with an antibiotic, the antibiotic minimizes benzoyl peroxide irritation by controlling inflammation and the benzoyl peroxide reduces the risk of antibiotic resistance by killing resistant strains of bacteria.Antibiotics can also reduce erythema in patients whose skin is irritated by the harsher topical retinoids.Adapalene, the least irritating of the topical retinoids, has anti-inflammatory effects that can be enhanced by the addition of an antibiotic....»
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 «...Topical antimicrobial agents are effective in the treatment of inflammatory disease. Benzoyl peroxide is a bactericide and is an excellent first-line medication. The response to this agent is rapid, with improvement noted as early as five days after treatment has begun, but irritation is common. Water-based products, as compared with alcohol based products, when used at low peroxide concentrations (5 to 5 percent) will help to limit this problem and have an efficacy similar to that of other products in this class. Benzoyl peroxide does not induce resistance; when used with topical or oral antibiotics, it protects against the development of this problem....»
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